Browsing by Author "Murugan, Nirosha J."

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The emission and application of patterned electromagnetic energy on biological systems.
(2017-03-31) Murugan, Nirosha J.
From the assembly of intricate biomolecules to the construction of tissues and organs from homogenous embryonic cells, patterns permeate throughout biological systems. Whereas molecules govern the multiform signalling pathways necessary to direct anatomy and physiology, biophysical correlates are inextricably paired to each and every chemical reaction – yielding a constant interplay between matter and energy. Electromagnetic energies represented as propagating photons or electromagnetic fields have shown to contain complex information that is specific to their paired molecular events. The central aim of this thesis was to determine whether these biophysical signatures or patterns can be obtained from biomolecules and subsequently be used in lieu of the chemical itself within a molecular cascade to elicit desired effects within biological systems. The findings presented here show that using a novel bioinformatics tool, namely the Cosic Resonant Recognition Model (RRM), biomolecules (proteins) can recognize their particular targets and vice versa by dynamic electromagnetic resonance. We also show using fundamental units of energies that this dynamic electromagnetic resonance is within the visible spectrum and can be used to define molecular pathways such as the ERK-MAP pathway, or distinctive viral proteins that mark certain pathogens such as Zika or Ebola viruses. Further findings presented herein show that these electromagnetic patterns derived from biomolecules can be detected using modern technologies such as photomultiplier tubes, and as every signature is unique to that system, can be used to identify insidious systems such as cancers from healthy populations. Furthermore, it is now possible to capture these unique electromagnetic signatures of biomolecules, parse the signals from the noise, and re-apply these patterns back onto systems to elicit effects such as altered proliferation rates of cancers or regenerative systems. The series of theoretical models and investigations outlined here clearly profiles the predominant electronic nature of the living matrix and its constituents, which lays the groundwork for reshaping our knowledge of cellular mechanisms that ultimately drive physiology, medicine and the development of effective diagnostic, preventative or therapeutic tools.
Physical and chemical changes in planarian and non-living aqueous systems from exposure to temporally patterned magnetic fields
(Laurentian University of Sudbury, 2013-11-11) Murugan, Nirosha J.
Planarian maintained in spring water and exposed for two hours to temporally patterned, weak (1 to 5 μT) magnetic field in the dark displayed diminished mobility that simulated the effects of morphine and enhanced this effect at concentrations associated with receptor subtypes. A single (5 hr) exposure to this same pattern following several days of exposure to a very complex patterned field in darkness dissolved the planarian and was associated with an expansion of their volume. Spectral power density analyses of direct measurements of the spring water only following exposure to this field in darkness showed emission spectra that were displayed from control conditions by ~10 nm and associated with an energy increment of ~10-20 J. This value is an intrinsic solution for the physical properties of the water molecule. “Shielding” the exposed water with plastic, aluminum foil or copper foil indicated that only the latter eliminated a powerful spike in photon emission around 280 nm. Continuous measurement of pH indicated that the slow shift towards alkalinity over 12 hours of exposure was associated with enhanced transient pH shifts of .02 units with typical durations between 20 and 40 ms. These results indicate that the appropriately patterned and amplitude of magnetic field that affects water directly could mediate some of the powerful effects displayed by biological aquatic systems.