Investigation of the effect of acute radiation on enteroendocrine L-cell health and function
dc.contributor.advisor | Dr. Jeffrey Gagnon | |
dc.contributor.author | Bonin, Patrice | |
dc.date.accessioned | 2025-02-04T18:36:47Z | |
dc.date.available | 2025-02-04T18:36:47Z | |
dc.date.issued | 2023-01-30 | |
dc.description.abstract | Radiation enteropathy is a commonly observed syndrome induced by abdominal and pelvic radiation therapy characterized by acute and/or chronic pain and loss of proper gut function. Glucagon-like peptide-2 (GLP-2), an important peptide hormone in the enhancement of proper intestinal function, proliferation of intestinal tissue and inhibition of enterocyte apoptosis, is a known treatment option of malabsorption disorders of the intestines. Recent developments have demonstrated that exogenous GLP-2 treatments attenuate and facilitate recovery of radiation- induced gut injury. This study aims to elucidate the effects of radiation therapy on endogenous GLP-2 secretion from intestinal L-cells as this is poorly understood. In mice, L-cell counts remained unchanged 48 hours post-irradiation but total circulating GLP-2 was increased. Irradiation of in-vitro L-cell models demonstrated a trend of increased hormone secretion at intermediate doses and significant increase in cell viability and mitochondrial activity. The stimulatory effect of radiation on L-cell should be investigated in future studies. | |
dc.identifier.uri | https://laurentian.scholaris.ca/handle/10219/4247 | |
dc.language.iso | en_CA | |
dc.publisher | Laurentian University Library & Archives | |
dc.rights.holder | Patrice Bonin | |
dc.rights.license | Laurentian University ETD license | |
dc.subject | Glucagon-like peptide-2, Gastrointestinal, Enteroendocrine, Ionizing radiation, L-cells | |
dc.title | Investigation of the effect of acute radiation on enteroendocrine L-cell health and function | |
dc.type | Thesis | |
thesis.degree.discipline | Biology | |
thesis.degree.grantor | Laurentian University (en_CA) | |
thesis.degree.level | 1 | |
thesis.degree.name | Master of Science (MSc) in Biology |