Investigation of the effect of acute radiation on enteroendocrine L-cell health and function

dc.contributor.advisorDr. Jeffrey Gagnon
dc.contributor.authorBonin, Patrice
dc.date.accessioned2025-02-04T18:36:47Z
dc.date.available2025-02-04T18:36:47Z
dc.date.issued2023-01-30
dc.description.abstractRadiation enteropathy is a commonly observed syndrome induced by abdominal and pelvic radiation therapy characterized by acute and/or chronic pain and loss of proper gut function. Glucagon-like peptide-2 (GLP-2), an important peptide hormone in the enhancement of proper intestinal function, proliferation of intestinal tissue and inhibition of enterocyte apoptosis, is a known treatment option of malabsorption disorders of the intestines. Recent developments have demonstrated that exogenous GLP-2 treatments attenuate and facilitate recovery of radiation- induced gut injury. This study aims to elucidate the effects of radiation therapy on endogenous GLP-2 secretion from intestinal L-cells as this is poorly understood. In mice, L-cell counts remained unchanged 48 hours post-irradiation but total circulating GLP-2 was increased. Irradiation of in-vitro L-cell models demonstrated a trend of increased hormone secretion at intermediate doses and significant increase in cell viability and mitochondrial activity. The stimulatory effect of radiation on L-cell should be investigated in future studies.
dc.identifier.urihttps://laurentian.scholaris.ca/handle/10219/4247
dc.language.isoen_CA
dc.publisherLaurentian University Library & Archives
dc.rights.holderPatrice Bonin
dc.rights.licenseLaurentian University ETD license
dc.subjectGlucagon-like peptide-2, Gastrointestinal, Enteroendocrine, Ionizing radiation, L-cells
dc.titleInvestigation of the effect of acute radiation on enteroendocrine L-cell health and function
dc.typeThesis
thesis.degree.disciplineBiology
thesis.degree.grantorLaurentian University (en_CA)
thesis.degree.level1
thesis.degree.nameMaster of Science (MSc) in Biology

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