RNA disruption in response to cellular stress

Abstract

RNA disruption is a novel cellular phenomenon that occurs under various cellular stress conditions and has a significant impact on cellular function. This critical review essay synthesizes research findings from a range of experiments performed over several years to present a comprehensive summary of the stressors that induce RNA disruption, the impact of RNA disruption on ribosomal proteins, the potential link between RNA disruption and other cellular phenomenon (e.g., apoptosis and autophagy), the molecular mechanism and the implications for disease treatment, specifically chemotherapeutic treatment. The review also identifies the weaknesses and/or limitations of the research performed to date and suggests methods to overcome them. Future research directions are proposed to address gaps in knowledge/understanding, such as utilizing other experimental techniques (e.g., LC-MS) to elucidate the key molecules involved in RNA disruption. By providing an in-depth critical analysis and suggesting options for improvement, this review aims to guide future research and provide a deeper understanding of RNA disruption.